A close-up view of codon selection in eukaryotic initiation
نویسندگان
چکیده
منابع مشابه
Principles of start codon recognition in eukaryotic translation initiation
Selection of the correct start codon during initiation of translation on the ribosome is a key event in protein synthesis. In eukaryotic initiation, several factors have to function in concert to ensure that the initiator tRNA finds the cognate AUG start codon during mRNA scanning. The two initiation factors eIF1 and eIF1A are known to provide important functions for the initiation process and ...
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Factors affecting translation of mRNA contribute to the complexity of eukaryotic proteomes. In some cases, translation of a particular mRNA can generate multiple proteins. However, the factors that determine whether ribosomes initiate translation from the first AUG codon in the transcript, from a downstream codon, or from multiple sites are not completely understood. Various mRNA properties, in...
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15 صفحه اولStructural Changes Enable Start Codon Recognition by the Eukaryotic Translation Initiation Complex
During eukaryotic translation initiation, initiator tRNA does not insert fully into the P decoding site on the 40S ribosomal subunit. This conformation (POUT) is compatible with scanning mRNA for the AUG start codon. Base pairing with AUG is thought to promote isomerization to a more stable conformation (PIN) that arrests scanning and promotes dissociation of eIF1 from the 40S subunit. Here, we...
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ژورنال
عنوان ژورنال: RNA Biology
سال: 2017
ISSN: 1547-6286,1555-8584
DOI: 10.1080/15476286.2017.1308998